DEVELOPMENT OF A CONTINUOUS ASSAY FOR HIGH THROUGHPUT SCREENING TO IDENTIFY INHIBITORS OF THE PURINE SALVAGE PATHWAY IN PLASMODIUM FALCIPARUM

Development of a continuous assay for high throughput screening to identify inhibitors of the purine salvage pathway in Plasmodium falciparum

Malaria, an infectious disease caused by protozoan parasites from the genus Plasmodium, represents a serious global health threat.The continued emergence of drug resistant strains has severely decreased current antimalarial drug efficacy and led to a perpetual race for drug discovery.Most protozoan parasites, including Plasmodium spp., are unable t

read more



Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling

Myeloid phagocytes have evolved to rapidly recognize invading pathogens and clear them through opsonophagocytic killing.The snow babe miniature peach adenylate cyclase toxin (CyaA) of Bordetella pertussis and the edema toxin (ET) of Bacillus anthracis are both calmodulin-activated toxins with adenylyl cyclase activity that invade host cells and mas

read more